Rebuild Ancient Protein To Reveal Ancient Eart Temperature

Researchers reconstruct proteins from ancient bacteria to measure the Earth's temperature over the ages. The scientists determined that the Earth endured a massive cooling period between 500 million and 3.5 billion years ago.

“By studying proteins encoded by these primordial genes, we are able to infer information about the environmental conditions of the early Earth,” said Eric Gaucher, Ph.D., president of scientific research at the Foundation for Applied Molecular Evolution in Gainesville and the study’s lead scientist. “Genes evolve to adapt to the environmental conditions in which an organism lives. Resurrecting these since long-extinct genes gives us the opportunity to analyze and dissect the ancient surroundings that have been recorded in the gene sequence. The genes essentially behave as dynamic fossils.”

Scientists rebuild ancient proteins to reveal primordial Earth's temperature

Internship in Bioinformatics

IBM T.J. Watson Research Center, Yorktown Heights, NY: The IBM Computational Biology Center is engaged in a research collaboration with the National Geographic Society on The Genographic Project (seehttp://www.ibm.com/genographic for more information). The hired candidate will work on design and implementation of algorithms for analysis of genotypic data. Unix/Linux and advanced programming skills (C/C++, Java, Perl, etc) a must. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability age, or veteran status.

Read more at : http://www.newyork.computerjobs.com/job_display.aspx?jobid=2058537

Employment :Postdoc positions on Plant Molecular genetics, genomics and bioinformatics, Pennsylvania State University-Main Campus, State College, PA, United States

Title: Postdoc positions on Plant Molecular genetics, genomics and
bioinformatics
Employer: Pennsylvania State University-Main Campus
Location: State College, PA, United States
Posted: Feb 10

Seeking two postdoctoral researchers to work on a newly funded project on a biofuel plant species. This is a three-year research project with the aim of utilizing the modern tools of genetics, genomics and biotechnology to facilitate development of a comprehensive research program for directed improvement of a biofuel crop. The main components of this project include development of genomics database, gene discovery, development of a comprehensive plant breeding program using molecular techniques, and designing and development of transgenic plants. The two postdoctoral incumbents will work together, however, one would focus mainly on development of genetic markers and maps and marker-assisted selection while the second would focus on functional genomics and bioinformatics. The successful candidates will have Ph.D. degree in a plant science discipline, including Plant Molecular Biology, Genetics, Biochemistry, Bioinformatics or other related fields.

Full details:
http://jobs.phds.org/job/7504/pennsylvania-state-university/postdoc-positions-on

Nanotechnology Research - Identifies Peptide "Fingerprint" in Both Forms of ALS

A new findings in biomedical using nanotechnology has been found by Troy Woof of Buffalo University.

It is the first time that a common molecular signature has been found in patients with both familial and sporadic cases, where no other family members have the disease, of ALS.

Nanotechnology Identifies Peptide "Fingerprint" in Both Forms of ALS - UB NewsCenter

This finding has been found using nanotechnology approach.

"Only nanotechnology is capable of identifying a species in these amounts," he said. "Because of the minute amounts of analyte that are present in some samples, nanospray technologies, in particular, which reveal what we call a peptide's mass 'fingerprint,' have emerged as one of the most important tools in the field of proteomics."

Nanotechnology Identifies Peptide "Fingerprint" in Both Forms of ALS - UB NewsCenter

The test has been done to identify a molecular signature common to both familial and sporadic cases of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

Amyotrophic lateral sclerosis (ALS, sometimes called Lou Gehrig's Disease, or Maladie de Charcot) is a progressive, usually fatal, neurodegenerative disease caused by the degeneration of motor neurons, the nerve cells in the central nervous system that control voluntary muscle movement. As one of the motor neuron diseases, the disorder causes muscle weakness and atrophy throughout the body as both the upper and lower motor neurons degenerate and die, ceasing to send messages to muscles. Unable to function, the muscles gradually weaken, develop fasciculations (twitches) because of denervation, and eventually atrophy due to that denervation. The patient may ultimately lose their ability to initiate and control all voluntary movement except of the eyes.

Amyotrophic lateral sclerosis - Wikipedia, the free encyclopedia

Engineering Approach Empower Bioinformatics

One of many approach has been design to simplified biological problem. Such as protein alignment and motif findings. A simple word to represent this approach is dry lab, instead using wet lab, that cost higher than dry lab. Science daily has said

The MIT researchers focused on a pathway in yeast that controls cells' response to a specific change in the environment. The resulting model is "the simplest model you can ever reduce these systems to," said Alexander van Oudenaarden, W.M. Keck Career Development Professor in Biomedical Engineering and Associate Professor of Physics and senior author of a paper describing the work in the Jan. 25 issue of Science.

Biological Pathway Models Simplified With Engineering Approach


Thus, this improvement will be wow to the world of bioinformatics